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Saturday, May 9, 2020 | History

2 edition of Studies on the immune responses of athymic mice found in the catalog.

Studies on the immune responses of athymic mice

Barbara Anne Croy

Studies on the immune responses of athymic mice

by Barbara Anne Croy

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  • 6 Currently reading

Published by s.n.] in [Toronto .
Written in English

    Subjects:
  • Immune response,
  • Nude mouse,
  • T cells

  • Edition Notes

    ContributionsToronto, Ont. University.
    The Physical Object
    Paginationvi, 106, [20] leaves, 12 leaves of plates :
    Number of Pages106
    ID Numbers
    Open LibraryOL20795829M

      Total 38 athymic nude mice were used in the experiment, and carbon dioxide (CO 2) inhalation was used for euthanasia of mice. Fecal sample collection and bacterial genomic DNA extraction Animal feces were collected from each mouse for two consecutive hours from to A.M. on day 0 (before the xenograft), and day 5 and day 10 after GpS treatment. Dietary arginine supplementation enhances immune responses to inactivated Pasteurella multocida vaccination in mice - Volume Issue 5 - Wenkai Ren, Lingxiu Zou, Nengzhang Li, Yan Wang, Gang Liu, Yuanyi Peng, Jiannan Ding, Lichuang Cai, Yulong Yin, Guoyao Wu.

    These mice lack antibody formation, cell-mediated immune responses, delayed-type hypersensitivity responses and also lack the capability of killing of virus-infected or malignant cells. Nude mice normally live for 6 months to a year. 1) Inbred wt mice deficient in certain immune cells are lethally irradiated with gamma irradiation to deplete hematopoeitic SCs 2) SCs are replaced by transfer of BM of another type of mouse to the irradiated mice (reconstitution- give abx for these 6 weeks).

    Local tumor control following single dose irradiation of human melanoma xenografts: Relationship to cellular radiosensitivity and influence of an immune response by the athymic mouse Full Record Other Related Research. the reason athymic mice are used in in-vivo cancer studies is because these mice lack thymus glands. hence they dont produce T cells. Therefore they dont reject tumor cells transplanted into them.


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Studies on the immune responses of athymic mice by Barbara Anne Croy Download PDF EPUB FB2

The responses of normal an athymic mice to infections by togaviruses: strain differentiation in active and adoptive immunization. J Gen Virol. Feb; 46 (2)– Gresser I, Tovey MG, Bandu ME, Maury C, Brouty-Boyé D.

Role of interferon in the pathogenesis of virus diseases in mice as demonstrated by the use of anti-interferon serum. by: 7. Active immunization of germfree nu/nu mice with Formalin-killed C. jejuni also did not protect the gnotobiotic mice from Campylobacter infection and diarrhea.

It appears from the results of our initial gnotobiotic studies that antibodies in serum against the infecting strain of C. jejuni may not play an essential role in resistance to Campylobacter disease in by:   The central role of the thymus in immunity was assessed in nude mice.

Nudes failed to reject allografts and xenografts and to respond to foreign erythrocytes but responded normally to endotoxin and pneumococcal by: 7.

The T-Cell-Mediated Immune Response of Mice to Herpes Simplex Virus. Authors; Authors and affiliations Much of this evidence comes from studies carried out in the mouse in which the precise nature of the T-cell response to herpes can readily be studied.

P., Phelan, J., McLean, C. S., and Field, H. J., b, Pathogenesis of herpes Cited by:   In summary, the present study indicates that athymic nude C57BL/6 mice are resistant to experimental cutaneous anthrax, apparently because of a superficial neutrophilic response that acts at an early point in the infectious process to clear the inoculated organisms before they can invade the underlying skin.

Abstract. The athymic nude (nu) mutation is now the most widely used of over known mutations in the mouse. The virtual absence of any cell-mediated immune response in these animals has proved to be of great value both in the study of the immune system itself and as a tool in many areas of applied research, particularly in the study of cancer and infectious disease.

Deficient and Sufficient Immune Systems in the Nude Mouse. W., and Rickard, M. D.,Studies on immune responses to larval cestodes in mice.

Increased susceptibility of certain E. J., Leenstra, F., and Elgersma, A., b, The use of congenitally athymic (nude) mice to study the possible thymus dependence of intestinal. Athymic nude mice, a murine strain bearing spontaneous deletion in the Foxn1 gene that causes deteriorated or absent thymus (which results in inhibited immune system with reduction of number of T.

A type of laboratory mouse that is hairless, lacks a normal thymus gland, and has a defective immune system because of a genetic mutation. Athymic nude mice are often used in cancer research because they do not reject tumor cells, from mice or other species.

Impaired immune responses are generated in tumor-bearing mice as well (Sano et al., ; Gillette and Boone, ). In the present study, we examined whether ONO can restore the immune responses in Meth A tumor-bearing mice.

Analysis of responsiveness of B lymphocytes has been greatly aided by the availability of athymic nude mice.

The immunological responsiveness of these mice to a wide range of stimuli has been reviewed and analyzed by H. Wortis. In at least one study, mice exhibiting immune enhancement following SARS virus challenge were noted to upregulate their Th1 cytokines and downregulate their anti-inflammatory cytokines such as IL, despite exhibiting eosinophilic infiltrates [ 24 ], although another study concluded lack of adequate Th1 induction was responsible [ 25 ].

CONCLUSION Comparative studies in athymic and euthymic animals can elucidate pathogenetic mechanism in which immune or non-immune defence systems are involved.

One such example is the clarification of the role ofT-lympho- cytes (CD4+ cells) in the pathogenesis of streptozotocin-induced diabetes mellitus in mice.

Local Immune Cell Response of Athymic Nude Mice Developing Orthotopic H/ Tumors Due to the lack of thymus maturation, a T-cell deficiency was observed in athymic nude mice.

B cells, dendritic cells, and granulocytes were all relatively intact, and there was a compensatory increase in both natural killer (NK)-cell activity and tumoricidal macrophages in these mice (as. A nude mouse is a laboratory mouse from a strain with a genetic mutation that causes a deteriorated or absent thymus, resulting in an inhibited immune system due to a greatly reduced number of T cells.

The phenotype of the mouse is a lack of body hair, which gives it the "nude" nickname. The nude mouse is valuable to research because it can receive many different types of tissue and tumor grafts, as it. Innate immune responses have been shown to contribute to the control of malaria infections in mice and there is indirect evidence that they also contribute to the control of infection in humans.

There are a variety of immunodeficient mice that can be used for PDX models: severely compromised immune-deficient (SCID) mice, athymic nude mice, non-obese diabetic (NOD)–SCID mice, and.

“Humanized” mice are used to study human immune responses, but they are inadequate for stem cell studies, say Stanford researchers. Optimized models are needed for clinical decision-making. Abstract. Background Previous studies in a murine cutaneous anthrax model have demonstrated that hairless and haired HRS/J mice are extremely resistant to Bacillus e these mice are relatively thymus deficient, we used C57BL/6 athymic nude and euthymic mice to evaluate the relationship between T cell deficiency and this heightened resistance.

Abstract. The congenitally athymic, nude mouse strain could hardly have arrived at a more opportune time than in the mid s (F lanagan ; P antelouris ). Only a few years earlier neonatally thymectomized mice had been shown to develop immunodeficiency (M iller ), the dual nature of the immune system was indicated by studies of chicken lacking either a bursa of Fabricius or both a.

Nude mice have a mutation in the gene FOXN1 which results in lack of fur. Since FOXN1 is very crucial for the development of thymus and several immune response especially T cell mediated response.Leukocyte Membrane Determinants Regulating Immune Reactivity is a result of the Leukocyte Culture Conference meeting held at Amsterdam in Abstracts presented in the meeting are compiled in this book.

The topics of these abstracts are all under leukocyte biology and include not just lymphocytes but also monocytes, macrophages, and.

It has been speculated that brain activities might directly control adaptive immune responses in lymphoid organs, although there is little evidence .